Publications
    • Ontoria JM, Rydberg EH, Di Marco S, Tomei L, Attenni B, Malancona S, Martin Hernando JI, Gennari N, Koch U, Narjes F, Rowley M, Summa V, Carroll SS, Olsen DB, De Francesco R, Altamura S, Migliaccio G, Carf� A. (2009) Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors. J Med Chem 52(16): 5217-27

 

    • Rydberg EH, Cellucci A, Bartholomew L, Mattu M, Barbato G, Ludmerer SW, Graham DJ, Altamura S, Paonessa G, De Francesco R, Migliaccio G, Carfi A. (2009) Structural basis for resistance of the genotype 2b Hepatitis C Virus NS5B polymerase to Site A non-nucleoside inhibitors. J Mol Bio 390(5): 1048-59

 

    • Zeev-Ben-Mordehai T, Paz A, Peleg Y, Toker L, Wolf SG, Rydberg EH, Sussman JL, Silman I. (2009) Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization. Protein Expr Purif 63(2): 147-157

 

    • Rydberg EH, Brumstein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang Y-P, Silman I, Sussman JL. (2006) Complexes of Alkylene-Linked Tacrine Dimers with Torpedo californica Acetylcholinesterase: Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge. J. Med. Chem. 49(18): 5491-5500

 

    • Prilusky JC, Felder C, Zeev-Ben-Mordehai T, Rydberg EH, Man O, Beckmann J, Silman I, Sussman JL. (2005) FoldIndex©: A Simple Tool to Predict Whether a Given Protein Sequence is Intrinsically Unfolded. Bioinfo 21: 3435-3438

 

    • Zeev-Ben-Mordehai T, Rydberg EH, Solomon A, Toker L, Auld VJ, Silman I, Botti S, Sussman JL. (2003) The Intracellular Tail of Drosphila Cholinesterase-like Neural Adhesion Protein, Gliotactin, is Natively Unfolded. Proteins 53:758-767

 

    • Rydberg EH, Overall CM, Brayer GD, and Withers SG. (2002). Mechanistic Analyses of Catalysis in Human Pancreatic alpha-Amylase: Detailed Kinetic and Structural Studies of Mutants of Three Conserved Carboxylic Acids. Biochem. 41(13): 4492-4502.

 

    • Brayer GD, Sidhu G, Maurus R, Rydberg EH, Braun C, Wang Y, Nguyen NT, Overall CM and Withers SG (2000). Subsite Mapping of the Human Pancreatic alpha-Amylase Active Site through Structural, Kinetic, and Mutagenesis Techniques. Biochem. 39(16): 4778-4791.

 

    • Rydberg EH, Sidhu G, Vo HC, Hewitt J, Côté HCF, Wang Y, Numao S, MacGillivray RTA, Overall CM, Brayer GD, Withers SG (1999) Cloning, Mutagenesis, and Structural Analysis of Human Pancreatic alpha-Amylase Expressed in Pichia pastoris. Protein Sci, 8: 635-643

 

    • Rydberg EH, Sidhu G, Overall CM, Brayer GD, and Withers SG. (1999). Investigating the roles of three crucial active-site residues of human pancreatic alpha-amylase. ABSTR PAP AM CHEM S 218: 48-CARB Part 1 AUG 22

 

    • Rydberg EH, Overall CM, Withers SG. (1997) Mechanistic studies of human pancreatic alpha-amylase. FASEB Journal 1 (9): 2654, Suppl. S JUL 31

 

    • Mithani S., Drew DM., Rydberg EH, Taylor NJ., Mooibroek S., Dmitrienko GI (1997) An Anomalous Reaction of 2-Benzenesulfonyl-3-Aryloxaziridines (Davis Reagents) with Indoles — Evidence for a Stepwise Reaction of the Davis Reagent with a Pi-Bond. J. Am. Chem. Soc. 119, 1159-1160

 

    • Grygorczyk R, Feighner SD, Adam M, Liu KK, Lecouter JE, Dashkevicz MP, Hreniuk DL, Rydberg EH, Arena JP (1996) Detection of Intracellular Calcium Elevations in Xenopus Laevis Oocytes — Aequorin Luminescence Versus Electrophysiology. J. Neurosci. Meth. 67, 19-25

 

  • Grygorczyk R, Arena J, Feighner S, Lecouter J, Rydberg EH. (1994) Comparison of Aequorin Luminescence and Electrophysiology as Intracellular Ca2+ Measures in Xenopus-Oocytes. Biophys. J. 66 (2): A441-A441 Part 2
Presentations
    • Rydberg EH, Zeev-Ben-Mordehai T, Macion R, Rees DM, Toker L, Botti S, Solomon A, Auld VJ, Silman I, Sussman JL. Large Scale Expression and Characterization of the Drosophila Gliotactin Extracellular, Cholinesterase-like, Domain and the Intracellular, Natively Unfolded, Domain. 28th International Meeting of the Federation of European Biological Sciences. Istanbul, Turkey.

 

    • Solomon A, Marcion R, Rees DM, Rydberg EH, Zeev Ben-Mordechai T, Botti S, Silman I, Sussman JL, Auld VJ. (2002) Large scale expression of the extracellular and cytoplasmic domains of the Drosphila adhesion protein Gliotactin. XIth International Symposium on Cholinergic Mechanisms. St. Moritz, Switzerland

 

    • Li C, Wang Y, Sidhu G, Maurus R, Rydberg E, Overall CM, Withers SG, Brayer GD. (2001) Modification of Inhibitor Structure in Active Site Variants of Human Pancreatic Alpha-Amylase. Annual Meeting of the American Crystallographic Association. Los Angeles, CA USA

 

    • Rydberg EH (1999) Investigations into the Mechanism of Human Pancreatic a-Amylase. Volcano Bioorganic Conference. Oral Presentation. Pack Forest, WA USA

 

    • Rydberg EH, Overall CM, Brayer GD, Withers SG (1998) Mechanistic Studies of Human Pancreatic a-Amylase. 81st Canadian Society for Chemistry Conference and Exhibition. Whistler, BC Canada.

 

    • Fletcher RS, Borkow G, Arion D, Rydberg EH, Syed K, Puterman I, Dmitrienko GI, and Parniak MA. (1995) Multi-target Inhibition of HIV-1 Reverse Transcriptase by N-(4-t-Butylbenzoyl)-2-hydroxy-1-naphthaldehyde Hydrazone. 78th Canadian Society for Chemistry Conference and Exhibition. Poster. Guelph, ON Canada.

 

  • Mithani S, Rydberg EH, Taylor NJ, Mooibroek S, and Dmitrienko GI. (1995) Oxidative Transformations Related to the Synthesis of Anti-tumor Antibiotic FR900482: Evidence for an Ionic Intermediate in Oxidation of Indoles by Davis’ Reagent. 78th Canadian Society for Chemistry Conference and Exhibition. Guelph, ON Canada.